Acute oral median lethal dose of haloxon and coumaphos in sheep as influenced by plasma A esterase.

Abstract

Determination of the acute oral medial lethal dose (LD50) of haloxon for lambs classified as to the presence or absence of plasma esterases (A esterase; EsA) rapidly hydrolyzing haloxon revealed markedly different values for the 2 phenotypes of sheep. The LD50 for EsA- lambs was 763 mg/kg of body weight with 95% confidence limits of 543 to 1,072 mg/kg. The acute oral LD50 for EsA+ lambs remains undetermined but was demonstrated to be in excess of 11,392 mg/kg. The acute oral LD50 for a closely related organophosphate (coumaphos) was not different in the 2 phenotypes of sheep.

• Authors: N F Baker, R A Fisk, C Stormont
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 41 Issue 11 Pg. 1857-9 (Nov 1980) ISSN: 0002-9645 [Print] United States
• PMID: 7212416 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anthelmintics
• Insecticides
• Organophosphorus Compounds
• Umbelliferones
• Esterases
• Coumaphos
• haloxon

Topics

• Administration, Oral
• Animals
• Anthelmintics (administration & dosage)
• Coumaphos (toxicity)
• Esterases (blood)
• Insecticides (toxicity)
• Lethal Dose 50
• Organophosphorus Compounds (toxicity)
• Sheep (blood)
• Sheep Diseases (chemically induced)
• Umbelliferones (toxicity)