Abstract |
Interaction of calcium regulating hormone, active form of vitamin D3, and aspirin (ASA) was studied in rats. One alpha-hydroxyvitamin D3 (1 alpha-OH-D3) produced a hypercalcemia in parathyroidectomized, thyroparathyroidectomized and thyroparathyroidectomized nephrectomized rats. The effect of 1 alpha-OH-D3 was inhibited by treatment with 200, 50 and 20 mg/kg p.o. of ASA. ASA did not stimulate the gut absorption of calcium in vitamin D deficient rats. These data suggest that ASA acts by inhibiting 1 alpha OH-D3 induced bone resorption. This is the first report demonstrating the inhibitory effect of ASA on bone resorption as induced by 1 alpha-OH-D3, although partial inhibition of bone resorption in vitro has been reported.
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Authors | K Ueno, H Kawashima, N Ohnuma, S Kurozumi, Y Hashimoto, H Orimo |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 30
Issue 5
Pg. 675-8
(Oct 1980)
ISSN: 0021-5198 [Print] Japan |
PMID | 7206373
(Publication Type: Journal Article)
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Chemical References |
- Hydroxycholecalciferols
- Aspirin
- Calcium
- alfacalcidol
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Topics |
- Animals
- Aspirin
(pharmacology)
- Bone Resorption
(drug effects)
- Calcium
(blood, metabolism)
- Hydroxycholecalciferols
(antagonists & inhibitors)
- Intestinal Absorption
(drug effects)
- Male
- Nephrectomy
- Parathyroid Glands
(surgery)
- Rats
- Thyroidectomy
- Vitamin D Deficiency
(metabolism)
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