Aspirin inhibition of hypercalcemic effect of 1 alpha-hydroxyvitamin D3 in rats.

Interaction of calcium regulating hormone, active form of vitamin D3, and aspirin (ASA) was studied in rats. One alpha-hydroxyvitamin D3 (1 alpha-OH-D3) produced a hypercalcemia in parathyroidectomized, thyroparathyroidectomized and thyroparathyroidectomized nephrectomized rats. The effect of 1 alpha-OH-D3 was inhibited by treatment with 200, 50 and 20 mg/kg p.o. of ASA. ASA did not stimulate the gut absorption of calcium in vitamin D deficient rats. These data suggest that ASA acts by inhibiting 1 alpha OH-D3 induced bone resorption. This is the first report demonstrating the inhibitory effect of ASA on bone resorption as induced by 1 alpha-OH-D3, although partial inhibition of bone resorption in vitro has been reported.
AuthorsK Ueno, H Kawashima, N Ohnuma, S Kurozumi, Y Hashimoto, H Orimo
JournalJapanese journal of pharmacology (Jpn J Pharmacol) Vol. 30 Issue 5 Pg. 675-8 (Oct 1980) ISSN: 0021-5198 [Print] JAPAN
PMID7206373 (Publication Type: Journal Article)
Chemical References
  • Hydroxycholecalciferols
  • Aspirin
  • Calcium
  • alfacalcidol
  • Animals
  • Aspirin (pharmacology)
  • Bone Resorption (drug effects)
  • Calcium (blood, metabolism)
  • Hydroxycholecalciferols (antagonists & inhibitors)
  • Intestinal Absorption (drug effects)
  • Male
  • Nephrectomy
  • Parathyroid Glands (surgery)
  • Rats
  • Thyroidectomy
  • Vitamin D Deficiency (metabolism)

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