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Efficacy of two dosage schedules of cephalexin in dermatologic infections.

Abstract
Is the administration of oral antibiotics four times a day as necessary as some pharmacokinetic studies indicate? The efficacy of cephalexin administered twice a day was compared to the same drug administered four times a day for the treatment of skin and skin structure infections due to staphylococcus and/or streptococcus. The 154 outpatients in this four-clinic study ranged in age from 1 month to more than 70 years. A random number table was used to assign patients to either the twice a day or the four times a day regimen. The total daily dosage was the same in each regimen. Administration twice a day proved equally effective to the four times a day regimen. Both regimens were more than 97 percent effective and side effects were minimal.
AuthorsA F DiMattia, M J Sexton, C R Smialowicz, W H Knapp Jr
JournalThe Journal of family practice (J Fam Pract) Vol. 12 Issue 4 Pg. 649-52 (Apr 1981) ISSN: 0094-3509 [Print] United States
PMID7205167 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Cephalexin
Topics
  • Adolescent
  • Adult
  • Aged
  • Cephalexin (administration & dosage, therapeutic use)
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Skin Diseases, Infectious (drug therapy)

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