Abstract |
Is the administration of oral antibiotics four times a day as necessary as some pharmacokinetic studies indicate? The efficacy of cephalexin administered twice a day was compared to the same drug administered four times a day for the treatment of skin and skin structure infections due to staphylococcus and/or streptococcus. The 154 outpatients in this four-clinic study ranged in age from 1 month to more than 70 years. A random number table was used to assign patients to either the twice a day or the four times a day regimen. The total daily dosage was the same in each regimen. Administration twice a day proved equally effective to the four times a day regimen. Both regimens were more than 97 percent effective and side effects were minimal.
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Authors | A F DiMattia, M J Sexton, C R Smialowicz, W H Knapp Jr |
Journal | The Journal of family practice
(J Fam Pract)
Vol. 12
Issue 4
Pg. 649-52
(Apr 1981)
ISSN: 0094-3509 [Print] United States |
PMID | 7205167
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Cephalexin
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Drug Administration Schedule
- Female
- Humans
- Infant
- Infant, Newborn
- Male
- Middle Aged
- Skin Diseases, Infectious
(drug therapy)
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