H-Y antigen expression in a case of XX true hermaphroditism.

Abstract

Cells from an XX true hermaphrodite expressed a reduced amount of H-Y antigen when compared with normal XY cells and with cells from his father, who had an XY/XX chromosomal constitution. His mother had a normal karyotype and was H-Y negative. The four brothers of the patient were clinically and karyotypically normal. An X-Y interchange followed by random inactivation of the X chromosome is proposed to explain the H-Y antigen titer found in the patient.

• Authors: C A Moreira-Filho, P G Otto, Z Mustacchi, O Frota-Pessoa, P A Otto
• Journal: Human genetics (Hum Genet) Vol. 55 Issue 3 Pg. 309-14 ( 1980) ISSN: 0340-6717 [Print] Germany
• PMID: 7203463 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• H-Y Antigen

Topics

• Child, Preschool
• Disorders of Sex Development (genetics, immunology)
• Female
• Gonads (pathology)
• H-Y Antigen (genetics)
• Humans
• Sex Chromosome Aberrations
• Translocation, Genetic
• X Chromosome