Abstract |
First reports about incongruous H-Y antigen status in male-to-female and female-to-male transsexuals have been published by us in 1979. Meanwhile H-Y antigen expression was analyzed with the cytotoxicity assay of Goldberg et al. in 61 transsexuals. In 55 cases H-Y antigen status was found discordant with the anatomical, chromosomal and hormonal sex and corresponded to the gender identity of transsexuals. The relative frequency was 0,91. In 33 male-to-female transsexuals 29 were H-Y negative, one was intermediate, three were H-Y positive. In 28 female-to-male transsexuals 25 were H-Y positive, one was intermediate, two were H-Y negative. The new findings of an incongruous H-Y antigen status in genuine transsexuals may lead to new considerations about the pathogenesis of the disease and about the function of H-Y antigen.
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Authors | W Eicher, M Spoljar, J D Murken, K Richter, H Cleve, S Stengel-Rutkowski |
Journal | Fortschritte der Medizin
(Fortschr Med)
Vol. 99
Issue 1-2
Pg. 9-12
(Jan 15 1981)
ISSN: 0015-8178 [Print] Germany |
Vernacular Title | Transsexualität und H-Y Antigen. |
PMID | 7203339
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Female
- H-Y Antigen
(genetics)
- Humans
- Karyotyping
- Male
- Transsexualism
(genetics)
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