Antifungal activity of fenticonazole in experimental dermatomycosis and candidiasis.

Abstract

The antifungal activity of alpha-(2,4-dichlorophenyl)-beta,N-imidazolylethyl 4-phenylthiobenzyl ether nitrate (fenticonazole, Rec 15/1476) in experimental dermatomycosis and candidiasis in guinea pigs was studied. Fenticonazole proved to be a very active drug with a healing capacity generally higher than that of the reference compounds. The adequate range of activity was from 1% to 3%, giving complete healing without relapses in 100% of cases treated. Fenticonazole is presently undergoing further experimental studies and on the basis of our results a clinical trial would therefore seem to be essential.

• Authors: M Veronese, D Barzaghi, A Bertoncini
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 31 Issue 12 Pg. 2137-9 ( 1981) ISSN: 0004-4172 [Print] Germany
• PMID: 7199314 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antifungal Agents
• Imidazoles
• Miconazole
• Clotrimazole
• fenticonazole

Topics

• Animals
• Antifungal Agents
• Candidiasis (drug therapy)
• Clotrimazole (therapeutic use)
• Dermatomycoses (drug therapy)
• Guinea Pigs
• Imidazoles (therapeutic use)
• Miconazole (therapeutic use)