[Interaction of coronary-active compounds and anti-inflammatory drugs on the coronary vascular system (author's transl)].

Abstract

The effect of acemetacin (Rantudil) and indomethacin, respectively, on coronary flow and O2-pressure in coronary sinus blood before and after i.v. injections of coronary active compounds was permanently registered in anesthetised closed-chest dogs. It was found that i.v. infections of 2 mg acemetacin/kg extended effects of i.v. injected morocromen. After administration of morocromen (4.0 mg/kg), carbocromen (2.0 mg/kg), or dipyridamole (0.4 mg/kg) the application of acemetacin or indomethacin, respectively, produced a markedly increased effect on the coronary blood vessels. Comparative studies of indole-derivatives, the Ca-antagonizing compounds prenylamine, verapamil, nifedipine, and the phosphodiesterase inhibitor papaverine showed no similar effects.

• Authors: H Jacobi, K R Jentzsch, W Lüdtke, H Schwarz
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 31 Issue 10 Pg. 1704-10 ( 1981) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Wechselwirkungen koronarwirksamer Substanzen und Entzündungshemmer auf das Koronargefässsystem.
• PMID: 7198446 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Cardiovascular Agents
• Coumarins
• Indoleacetic Acids
• Morpholines
• acemetacin
• Dipyridamole
• morocromen
• Chromonar
• Indomethacin

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Cardiovascular Agents (pharmacology)
• Chromonar (pharmacology)
• Coronary Circulation (drug effects)
• Coumarins (pharmacology)
• Dipyridamole (pharmacology)
• Dogs
• Drug Interactions
• Female
• Indoleacetic Acids (pharmacology)
• Indomethacin (pharmacology)
• Male
• Morpholines (pharmacology)
• Myocardium (metabolism)
• Oxygen Consumption (drug effects)