[Antineoplastic activity of lambdamycin in different murine test models compared with cyclophosphamide, 6-mercaptopurine and 5-fluorouracil (author's transl)].

Abstract

Lambdamycin, a chromoglycoside antibiotic like chartreusin was found to be very active against leukemias L 1210 and P 388 and moderate effective against melanoma B 16 and Lewis lung carcinoma of mice. It was nearly without any effect when tested on Walker 256 carcinoma of rats. The effectiveness of lambdamycin was compared with that of cyclophosphamide, 5-fluorouracil and 6-mercaptopurine.

• Authors: W Gutsche, K Wohlrabe, W Jungstand, W F Fleck
• Journal: Archiv fur Geschwulstforschung (Arch Geschwulstforsch) Vol. 51 Issue 5 Pg. 398-404 ( 1981) ISSN: 0003-911X [Print] Germany
• Vernacular Title: Antineoplastische Wirksamkeit von Lambdamycin an verschiedenen murinen Testmodellen im Vergleich zur Wirkung von Cyclophosphamid, 6-Mercaptopurin and 5-Fluoruracil.
• PMID: 7197906 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Benzopyrans
• Glycosides
• Cyclophosphamide
• Mercaptopurine
• chartreusin
• Fluorouracil

Topics

• Animals
• Benzopyrans
• Carcinoma (drug therapy)
• Cyclophosphamide (therapeutic use)
• Fluorouracil (therapeutic use)
• Glycosides (therapeutic use)
• Leukemia, Experimental (drug therapy)
• Melanoma (drug therapy)
• Mercaptopurine (therapeutic use)
• Mice
• Rats