Opiatelike actions of eseroline, an eserine derivative.

Abstract	Eseroline, an eserine derivative without anticholinesterase activity, was tested in several systems for opiatelike activity. Eseroline depressed the twitch of the field-stimulated guinea pig ileum myenteric plexus longitudinal muscle preparation but failed to depress the twitch of the rat vas deferens. Intraperitoneal injections of eseroline in rats induced naloxone-antagonizable analgesia and catalepsy. Eseroline failed to influence the release of acetylcholine from the cortex of anesthetized rats. These observations have implications for studies in which eserine is used as a pharmacological tool.
Authors	K Jhamandas, J Elliott, M Sutak
Journal	Canadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 59 Issue 3 Pg. 307-10 (Mar 1981) ISSN: 0008-4212 [Print] Canada
PMID	7194726 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Analgesics Indoles Narcotics Naloxone Acetylcholine eseroline
Topics	Acetylcholine (metabolism) Analgesics Animals Catalepsy (chemically induced) Cerebral Cortex (drug effects, metabolism) Guinea Pigs Humans Indoles (antagonists & inhibitors, pharmacology) Male Muscle Contraction (drug effects) Naloxone (pharmacology) Narcotics Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!