Abstract |
[Ile3, Arg8] vasopressin (arginine- vasotocin), as well as the C-terminal tripeptides of the neurohypophyseal hormones arginine and lysine vasopressin, Pro-Arg-Gly-NH2 and Pro-Lys-Gly-NH2, were protective against puromycin-induced amnesia in mice when administered 24h before training. The N-protected tripeptide derivative, Z-Pro-Lys-Gly-NH2, was effective when given 5 days before training. The effectiveness of all peptides to attenuate puromycin-induced amnesia decreased as the interval between training and peptide treatment increased, indicating that the peptides influence memory processes, rather than general arousal. Z-Pro-Lys-Gly-NH2 was active at 24h after training, when the other peptides were no longer effective. Although it seems clear that neurohypophyseal hormones per se can attenuate puromycin-induced amnesia, these results are in line with the possibility that some portion of hormone action may be mediated via formation of longer-lived hormone fragments in the CNS.
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Authors | R Walter, P L Hoffman, J B Flexner, L B Flexner |
Journal | International journal of peptide and protein research
(Int J Pept Protein Res)
Vol. 16
Issue 5
Pg. 482-6
(Nov 1980)
ISSN: 0367-8377 [Print] Denmark |
PMID | 7194322
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Neurophysins
- Oligopeptides
- Vasopressins
- Arginine Vasopressin
- prolyl-arginyl-glycinamide
- Puromycin
- prolyl-lysyl-glycinamide
- Arginine
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Topics |
- Amnesia
(chemically induced)
- Animals
- Arginine
(pharmacology)
- Arginine Vasopressin
(pharmacology)
- Humans
- Hypothalamus
(metabolism)
- Memory
(drug effects)
- Mice
- Neurophysins
(pharmacology)
- Oligopeptides
(pharmacology)
- Puromycin
- Time Factors
- Vasopressins
(pharmacology)
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