Induction of digestive tract tumors and leukemias in Donryu rats by administration of 1-amyl-1-nitrosourea in drinking water.

Abstract

The effects of administration of 1-amyl-1-nitrosourea (ANU) at doses of 400, 200, 100 and 0 ppm in the drinking water to Donryu rats of both sexes were studied. Tumors developed in 166/205 (81%) rats that received ANU, as compared with 9/34 (27%) control rats. The incidence of digestive tract tumors was highest (76%), followed by hematopoietic tissue (11%) and liver (9%) tumors. In females, mammary tumors were also found. There appeared to be a dose-response relationship among the 3 treated groups as regards the incidence of tumors of the hematopoietic tissues and the average survival time.

• Authors: K Fujii, M Nakadate, T Ogiu, S Odashima
• Journal: Gan (Gan) Vol. 71 Issue 4 Pg. 464-70 (Aug 1980) ISSN: 0016-450X [Print] Japan
• PMID: 7191813 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nitrosourea Compounds
• 1-amyl-1-nitrosourea

Topics

• Animals
• Digestive System Neoplasms (chemically induced, pathology)
• Dose-Response Relationship, Drug
• Female
• Leukemia, Experimental (chemically induced, pathology)
• Male
• Mammary Neoplasms, Experimental (chemically induced, pathology)
• Neoplasms, Experimental (chemically induced, pathology)
• Nitrosourea Compounds (administration & dosage, toxicity)
• Rats
• Water Supply