Effect of calcium antagonist, etafenone hydrochloride, on the isolated guinea pig tracheal tissues.

Abstract

The present investigation was conducted to study the effect of 2'-[2-(diethylamino)ethoxy]-3-phenylpropiophenone hydrochloride (etafenone hydrochloride) on the action of various bronchoactive agents using isolated guinea pig tracheal tissues. Acetylcholine hydrochloride, prostaglandin F2a, histamine dihydrochloride and serotonin-creatinine sulfate induced contractile responses in guinea pig tracheal tissues were attenuated, while, isoprenaline hydrochloride, prostaglandin E2, salbutamol hemisulfate, aminophylline and adrenaline-induced relaxing responses were potentiated with continuous infusion of etafenone hydrochloride. These results suggest that etafenone hydrochloride would become a useful therapeutic agent in the treatment of chronic obstructive pulmonary disease.

• Authors: S Kitamura, Y Ishihara
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 30 Issue 7 Pg. 1088-91 ( 1980) ISSN: 0004-4172 [Print] Germany
• PMID: 7191291 (Publication Type: Journal Article)

Chemical References

• Propiophenones
• etafenone
• Propafenone
• Calcium

Topics

• Airway Resistance (drug effects)
• Animals
• Calcium (antagonists & inhibitors)
• Drug Interactions
• Guinea Pigs
• In Vitro Techniques
• Male
• Muscle Contraction (drug effects)
• Muscle, Smooth (drug effects)
• Propafenone (analogs & derivatives)
• Propiophenones (pharmacology)
• Trachea (drug effects)