Abstract |
To determine the clinical and functional characteristics of isolated platelet factor 3 (PF-3) deficiency, platelet function studies were carried out in 316 patients who were suspected of having a bleeding tendency. Although PF-3 abnormality was observed in 69 patients (22%), an isolated PF-3 abnormality was noted in only three patients. The abnormality was congenital in one patient and secondary to Hashimoto's thyroiditis, Ehlers-Danlos syndrome, and chronic myelocytic leukemia in the other two. Further investigations in the patient with congenital abnormality disclosed that PF-3 activity failed to respond to any of the stimuli tested, and there was a clear dissociation between PF-3 availability and platelet aggregation. The abnormality was due to an intrinsic platelet defect caused by a true deficiency of the membrane phospholipid clotting activity. The findings clearly establish that isolated PF-3 deficiency is an entity of qualitative platelet disorders that may be associated with a severe bleeding tendency.
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Authors | I M Minkoff, K K Wu, J Walasek, B Lightfoot, C Smith-McKearn |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 140
Issue 3
Pg. 366-7
(Mar 1980)
ISSN: 0003-9926 [Print] United States |
PMID | 7189110
(Publication Type: Journal Article)
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Topics |
- Blood Coagulation Tests
- Blood Platelet Disorders
(complications, diagnosis)
- Hemorrhage
(diagnosis, etiology)
- Humans
- Platelet Aggregation
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