Chronic effects of PGBx, a polymeric prostaglandin, on blood leukocyte counts.

Abstract

PGBx, a polymeric prostaglandin, in chronic doses therapeutic for hereditary diabetes and hereditary obesity in mice, produces significant increases of blood neutrophils and lymphocytes in normal mice, hereditary diabetic mice, and hereditary obese mice. For lymphocytes, but not for neutrophils, the direction of the PGBx effect reverses at doses above 10 micrograms/g of body weight.

• Authors: E Polis, F W Cope
• Journal: Physiological chemistry and physics (Physiol Chem Phys) Vol. 14 Issue 5 Pg. 431-7 ( 1982) ISSN: 0031-9325 [Print] United States
• PMID: 7186639 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Polymers
• Prostaglandins
• Prostaglandins B
• prostaglandin Bx

Topics

• Animals
• Diabetes Mellitus, Experimental (blood)
• Leukocyte Count
• Lymphocytes (drug effects)
• Mice
• Mice, Obese (blood)
• Neutrophils (drug effects)
• Polymers (therapeutic use)
• Prostaglandins (pharmacology)
• Prostaglandins B (pharmacology, therapeutic use)