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Role of antibiotics in penetrating abdominal trauma.

Abstract
The effectiveness of antibiotics in the management of penetrating abdominal injuries was studied retrospectively in two non-controlled, non-randomized groups of patients. The uncontrolled group (107 patients) received a variety of antibiotic(s) mainly intra- and postoperatively. The protocol group (121 patients) received a combination of clindamycin and gentamicin preoperatively in the Emergency Room. The protocol group had a statistically significant reduction in the incidence of intraabdominal sepsis, 1.7% as compared to 8.3% in the uncontrolled group. Although the improved results cannot be attributed solely to the antibiotic regimen, the trend seems apparent. Therefore, to minimize septic complications in penetrating abdominal injuries, we advocate: 1. prompt resuscitation, 2. early and appropriate surgical intervention and 3. preoperative antibiotics that are effective against both the aerobic and anerobic resident flora of the gastrointestinal tract.
AuthorsV A O'Donnell, Lou Sister, J L Alexander, A K Mandal
JournalThe American surgeon (Am Surg) Vol. 44 Issue 9 Pg. 574-7 (Sep 1978) ISSN: 0003-1348 [Print] United States
PMID717907 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
Topics
  • Abdominal Injuries (drug therapy)
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents (therapeutic use)
  • Child
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Wound Infection (prevention & control)
  • Wounds, Gunshot (drug therapy)
  • Wounds, Penetrating (drug therapy)
  • Wounds, Stab (drug therapy)

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