Abstract |
The effectiveness of antibiotics in the management of penetrating abdominal injuries was studied retrospectively in two non-controlled, non-randomized groups of patients. The uncontrolled group (107 patients) received a variety of antibiotic(s) mainly intra- and postoperatively. The protocol group (121 patients) received a combination of clindamycin and gentamicin preoperatively in the Emergency Room. The protocol group had a statistically significant reduction in the incidence of intraabdominal sepsis, 1.7% as compared to 8.3% in the uncontrolled group. Although the improved results cannot be attributed solely to the antibiotic regimen, the trend seems apparent. Therefore, to minimize septic complications in penetrating abdominal injuries, we advocate: 1. prompt resuscitation, 2. early and appropriate surgical intervention and 3. preoperative antibiotics that are effective against both the aerobic and anerobic resident flora of the gastrointestinal tract.
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Authors | V A O'Donnell, Lou Sister, J L Alexander, A K Mandal |
Journal | The American surgeon
(Am Surg)
Vol. 44
Issue 9
Pg. 574-7
(Sep 1978)
ISSN: 0003-1348 [Print] United States |
PMID | 717907
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Abdominal Injuries
(drug therapy)
- Adolescent
- Adult
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Child
- Female
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Wound Infection
(prevention & control)
- Wounds, Gunshot
(drug therapy)
- Wounds, Penetrating
(drug therapy)
- Wounds, Stab
(drug therapy)
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