Cyclo (His-Pro): mapping hypothalamic sites for its hypothermic action.

Abstract

Hypothalamic loci of Sprague-Dawley rats were individually injected with cyclo (His-Pro) to determine the sites where that metabolite of thyrotropin-releasing hormone acts to produce hypothermia. There was almost always a positive hypothermic response in the preoptic-anterior hypothalamic area (POA/AHA); injection into the posterior or middle hypothalamic areas or into the hippocampus caused no significant decrease in core temperature. The fact that only injection into the POA/AHA evoked hypothermia suggests that this area is a major hypothalamic site of action of cyclo (His-Pro) in modulating thermoregulation in the rat.

• Authors: J J Jacobs, C Prasad, J F Wilber
• Journal: Brain research (Brain Res) Vol. 250 Issue 2 Pg. 205-9 (Nov 04 1982) ISSN: 0006-8993 [Print] Netherlands
• PMID: 7171986 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Peptides, Cyclic
• Piperazines
• histidyl-proline diketopiperazine

Topics

• Animals
• Anterior Hypothalamic Nucleus (drug effects)
• Body Temperature Regulation (drug effects)
• Brain Mapping
• Hypothalamus (drug effects)
• Hypothalamus, Middle (drug effects)
• Hypothalamus, Posterior (drug effects)
• Injections, Intraventricular
• Male
• Peptides, Cyclic (pharmacology)
• Piperazines (pharmacology)
• Preoptic Area (drug effects)
• Rats
• Rats, Inbred Strains