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Identification of 4,6-dioxoheptanoic acid (succinylacetone), 3,5-dioxooctanedioic acid (succinylacetoacetate) and 4-Oxo-6-hydroxyheptanoic acid in the urine from patients with hereditary tyrosinemia.

Abstract
In the urine from patients with hereditary tyrosinemia, three characteristic compounds have been found. They have been identified as 4,6-dioxoheptanoic acid (succinylacetone), 3,5-dioxooctanedioic acid (succinyl-acetoacetate) and 4-oxo-6-hydroxyheptanoic acid. The identities have been established by mass spectrometry of several derivatives, and by comparison with a synthetic sample of 4,6-dioxoheptanoic acid.
AuthorsB Lindblad, G Steen
JournalBiomedical mass spectrometry (Biomed Mass Spectrom) Vol. 9 Issue 10 Pg. 419-24 (Oct 1982) ISSN: 0306-042X [Print] England
PMID7171740 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acetoacetates
  • Heptanoates
  • Heptanoic Acids
  • Tyrosine
  • succinylacetone
  • succinylacetoacetate
  • 4-oxo-6-hydroxyheptanoic acid
Topics
  • Acetoacetates (urine)
  • Amino Acid Metabolism, Inborn Errors (urine)
  • Gas Chromatography-Mass Spectrometry
  • Heptanoates (urine)
  • Heptanoic Acids (urine)
  • Humans
  • Tyrosine (metabolism)

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