Metabolism of monoamines in malignant hyperthermia-susceptible pigs.

Abstract

A comparison of monoamine oxidase activities in the hypothalamus and striatum between malignant hyperthermia-susceptible (Pietrain) and malignant hyperthermia-resistant (Landrace/Large White) pigs showed no significant difference between the two breeds. The concentrations of noradrenaline, dopamine and their non-O-methylated metabolites did not reflect the low activities of monoamine oxidase type A differentially. The malignant hyperthermia-susceptible pigs had significantly greater concentrations of 3,4-dihydroxyphenyl glycol in the striatum, and of 3,4-dihydroxymandelic acid in the hypothalamus. Consequently, in the brain, low monoamine oxidase type A activity does not appear to be involved in susceptibility to malignant hyperthermia. In addition, monoamine oxidase activities in the heart, liver, kidney and intestinal mucosa and catechol-O-methyl transferase activities in the kidney were the same in the susceptible and resistant pigs.

• Authors: M E Bardsley, A M Wheatley, C J Fowler, J M McCrodden, J V McLoughlin, K F Tipton
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 54 Issue 12 Pg. 1313-8 (Dec 1982) ISSN: 0007-0912 [Print] England
• PMID: 7171419 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amines
• Monoamine Oxidase
• Catechol O-Methyltransferase
• Dopamine
• Norepinephrine

Topics

• Amines (metabolism)
• Animals
• Catechol O-Methyltransferase (metabolism)
• Corpus Striatum (enzymology, metabolism)
• Disease Susceptibility
• Dopamine (metabolism)
• Hypothalamus (enzymology, metabolism)
• Malignant Hyperthermia (enzymology, metabolism)
• Monoamine Oxidase (metabolism)
• Norepinephrine (metabolism)
• Swine