Abstract |
A patient with an abdominal tumor and gastric cancer was treated with intraperitoneal OK-432 alone. Her general condition improved and the abdominal mass diminished significantly. The fluoroscopic radiography and gastroduodenal fiberscopic examinations revealed a slight improvement. Four months after the initiation of OK-432 therapy, microscopic examination of the biopsy specimen disclosed degenerated tumor cells with a pronounced accumulation of lymphocytes and large monocytes which were ascertained to be macrophages by the fluorescent antibody technique using anti-macrophage serum. This study revealed one possible mechanism of the antitumor action of OK-432.
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Authors | H Yamagishi, H Ishibashi, M Kodama, T Tanaka, Y Harada, I Hashimoto |
Journal | The Japanese journal of surgery
(Jpn J Surg)
Vol. 12
Issue 6
Pg. 434-41
( 1982)
ISSN: 0047-1909 [Print] Japan |
PMID | 7166915
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biological Products
- Picibanil
|
Topics |
- Biological Products
(therapeutic use)
- Female
- Humans
- Injections, Intramuscular
- Injections, Intraperitoneal
- Leukocyte Count
- Lymphocytes
(cytology)
- Middle Aged
- Picibanil
(administration & dosage, therapeutic use)
- Radiography
- Skin Tests
- Stomach Neoplasms
(diagnostic imaging, drug therapy, immunology)
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