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A patient with gastric carcinoma improved remarkably on intraperitoneal OK-432 therapy.

Abstract
A patient with an abdominal tumor and gastric cancer was treated with intraperitoneal OK-432 alone. Her general condition improved and the abdominal mass diminished significantly. The fluoroscopic radiography and gastroduodenal fiberscopic examinations revealed a slight improvement. Four months after the initiation of OK-432 therapy, microscopic examination of the biopsy specimen disclosed degenerated tumor cells with a pronounced accumulation of lymphocytes and large monocytes which were ascertained to be macrophages by the fluorescent antibody technique using anti-macrophage serum. This study revealed one possible mechanism of the antitumor action of OK-432.
AuthorsH Yamagishi, H Ishibashi, M Kodama, T Tanaka, Y Harada, I Hashimoto
JournalThe Japanese journal of surgery (Jpn J Surg) Vol. 12 Issue 6 Pg. 434-41 ( 1982) ISSN: 0047-1909 [Print] Japan
PMID7166915 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biological Products
  • Picibanil
Topics
  • Biological Products (therapeutic use)
  • Female
  • Humans
  • Injections, Intramuscular
  • Injections, Intraperitoneal
  • Leukocyte Count
  • Lymphocytes (cytology)
  • Middle Aged
  • Picibanil (administration & dosage, therapeutic use)
  • Radiography
  • Skin Tests
  • Stomach Neoplasms (diagnostic imaging, drug therapy, immunology)

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