Trimethoprim, metioprim, tetroxoprim, and RO 10-5970 in canine bone.

Abstract

The penetration of trimethoprim and three derivatives into bone tissue was investigated in a dog model. Our data demonstrated that the trimethoprim derivative RO 10-5970 concentrates well in bone tissue with median tissue-to-serum concentration ratios of 0.23 in cortical bone and 0.81 in both medulla and cancellous bone. The use of RO 10-5970 in osseous infections is appealing because oral administration is possible; therefore, clinical trials appear warranted.

• Authors: P Iversen, P O Madsen
• Journal: Acta pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 51 Issue 5 Pg. 446-9 (Nov 1982) ISSN: 0001-6683 [Print] Denmark
• PMID: 7164825 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Pyrimidines
• tetroxoprim
• Trimethoprim
• metioprim
• brodimoprim

Topics

• Animals
• Bone and Bones (metabolism)
• Dogs
• Male
• Pyrimidines (metabolism)
• Trimethoprim (analogs & derivatives, blood, metabolism)