Abstract |
Ethyl-2-cyanoacrylate was applied to the cortex of rabbits to evaluate its bioadhesive and histotoxic behavior. The animals were killed at 4 or 10 days. Half of the animals were pretreated with dexamethasone. Our results indicate that the application of ethyl-2-cyanoacrylate to brain tissue produced severe superficial cortical necrosis but not bioadhesion. Pretreatment with steroids did not provide a significant protective effect.
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Authors | B J Zumpano, L R Jacobs, J B Hall, G Margolis, E Sachs Jr |
Journal | Surgical neurology
(Surg Neurol)
Vol. 18
Issue 6
Pg. 452-7
(Dec 1982)
ISSN: 0090-3019 [Print] United States |
PMID | 7163966
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyanoacrylates
- ethyl 2-cyanoacrylate
- Dexamethasone
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Topics |
- Adhesiveness
- Animals
- Behavior, Animal
(drug effects)
- Brain
(drug effects, pathology)
- Chemical Phenomena
- Chemistry
- Cyanoacrylates
(toxicity)
- Dexamethasone
(pharmacology)
- Necrosis
- Rabbits
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