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Bioadhesive and histotoxic properties of ethyl-2-cyanoacrylate.

Abstract
Ethyl-2-cyanoacrylate was applied to the cortex of rabbits to evaluate its bioadhesive and histotoxic behavior. The animals were killed at 4 or 10 days. Half of the animals were pretreated with dexamethasone. Our results indicate that the application of ethyl-2-cyanoacrylate to brain tissue produced severe superficial cortical necrosis but not bioadhesion. Pretreatment with steroids did not provide a significant protective effect.
AuthorsB J Zumpano, L R Jacobs, J B Hall, G Margolis, E Sachs Jr
JournalSurgical neurology (Surg Neurol) Vol. 18 Issue 6 Pg. 452-7 (Dec 1982) ISSN: 0090-3019 [Print] United States
PMID7163966 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cyanoacrylates
  • ethyl 2-cyanoacrylate
  • Dexamethasone
Topics
  • Adhesiveness
  • Animals
  • Behavior, Animal (drug effects)
  • Brain (drug effects, pathology)
  • Chemical Phenomena
  • Chemistry
  • Cyanoacrylates (toxicity)
  • Dexamethasone (pharmacology)
  • Necrosis
  • Rabbits

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