Abstract | UNLABELLED: The use of new cardiotonic drugs, such as AR-L 115 BS (ARL), in patients with coronary artery disease (CAD) might be limited by their aggravating myocardial ischemia (MIS). Accordingly, we investigated ARL's (2 mg/kg BW i.v.) hemodynamics, myocardial oxygen consumption (MVO2) and regional wall motion (RWM) in 30 patients with CAD presenting with pacing-induced MIS (angina, rise of LVEDP, lactate production). ARL improved LV-pump function in 13 group-1 patients (average increases: cardiac index by +25%; LV-work by +17%; dp/dtmax by +30%; coronary sinus flow by +39%), while there was a decrease in preload (LVEDP by -44%) and afterload (AOMP by -9%) and cardiac efficiency by -25%. Such ARL-effects required a rise of MVO2 by +41% but did not induce MIS. These beneficial results were corroborated by significant hemodynamic improvements also in 17 group-2 patients when comparing the non-medicated immediate post-pacing period (PPP) with MIS versus the ARL-medicated PPP (= PPP + ARL) without MIS, where RWM improved by an overall average of 26 +/- 11% in the phase PPP + ARL. CONCLUSION: In CAD ARL improves hemodynamics and RWM. The mechanism is pre- and afterload reduction, increase in contractility, MVO2 and CSF without MIS being induced.
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Authors | J Thormann, M Schlepper, W Kramer, M Gottwik |
Journal | Zeitschrift fur Kardiologie
(Z Kardiol)
Vol. 71
Issue 11
Pg. 736-46
(Nov 1982)
ISSN: 0300-5860 [Print] Germany |
Vernacular Title | Mechanismus und Auswirkungen des Kardiotonikums AR-L 115 BS bei Patienten mit koronarer Herzkrankheit: verbesserte Ventrikelfunktion und regionale Wandbeweglichkeit ohne Angina pectoris. |
PMID | 7157928
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Cardiotonic Agents
- Imidazoles
- sulmazole
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Topics |
- Cardiotonic Agents
(therapeutic use)
- Coronary Circulation
(drug effects)
- Coronary Disease
(drug therapy)
- Heart Function Tests
- Heart Ventricles
(drug effects)
- Humans
- Imidazoles
(therapeutic use)
- Middle Aged
- Myocardial Contraction
(drug effects)
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