[Treatment of amibiasis with short-term secnidazole therapy].

Abstract

The authors have treated: a) 48 cases of E. histolytica histolytica intestinal amoebiasis by a single dose of 35 mg/kg of secnidazole with 98 p. 100 of parasitological success; b) 122 cases of E. histolytica minuta with several procedures: a unique dose of 25 mg/kg gives no success in 16.6 p. 100 of the cases, but the same single dose during three days gets only 2 p. 100 of failure; c) 22 cases of hepatic amoebiasis by a daily dose of 25 to 33 mg/kg during 5 days with success in every cases. Tolerance has been excellent. These short cures, facilitated by the long half-life of secnidazole are particularly easy to apply in developing countries.

• Authors: J Cesari, M Condat, Y Gendron, P Saint-Andre, J Thomas, G Charmot
• Journal: Medecine tropicale : revue du Corps de sante colonial (Med Trop (Mars)) 1982 Sep-Oct Vol. 42 Issue 5 Pg. 527-30 ISSN: 0025-682X [Print] France
• Vernacular Title: Le traitement de l'amibiase par le secnidazole en cure courte.
• PMID: 7154901 (Publication Type: English Abstract, Journal Article)

Chemical References

• Metronidazole
• secnidazole

Topics

• Adult
• Amebiasis (drug therapy)
• Child
• Drug Administration Schedule
• Dysentery, Amebic (drug therapy)
• Entamoebiasis (drug therapy)
• Female
• Humans
• Liver Abscess, Amebic (drug therapy)
• Male
• Metronidazole (administration & dosage, adverse effects, analogs & derivatives)