[Calcium antagonists in stress angina pectoris (pharmacodynamic study)].

Abstract

In 10 patients with stress stenocardia pharmacodynamics of Isoptin was studied with the aid of identical physical loads on the treadmill repeated with an hour's interval for 5-6 hours. A clearcut antianginal effect was recorded which consisted in the reduction of ST segment depression and of the pain syndrome for 5 hours after administration of 3 tablets over 5 hours and for 6 hrs 20 min after administration of 5 tablets of both drugs. The degree of effect increased considerably after the dose of isoptin was enhanced and was not changed after the dose of corinfar was enhanced. Difference in the haemodynamic effect of the drugs was found in their effect on the cardiac rate. Corinfar increased the cardiac rate, isoptin decreased it.

• Authors: S A Nikolenko, V I Metelitsa, N A Shinbaeva, K L Savvateev
• Journal: Kardiologiia (Kardiologiia) Vol. 22 Issue 11 Pg. 31-7 (Nov 1982) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Antagonisty kal'tsiia pri stenokardii napriazheniia (farmakodinamicheskoe issledovanie).
• PMID: 7154504 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Calcium Channel Blockers
• Pyridines
• Verapamil
• Nifedipine

Topics

• Adult
• Angina Pectoris (drug therapy, physiopathology)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (pharmacology)
• Dose-Response Relationship, Drug
• Electrocardiography
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged
• Nifedipine (pharmacology)
• Pyridines (pharmacology)
• Verapamil (pharmacology)