alpha-Bungarotoxin displacing antibody in myasthenia gravis.

Abstract

The majority of sera from myasthenic patients cannot precipitate all available receptor-toxin complex even in conditions of a 4,000-fold excess of antibody. This effect was traced to displacement of toxin from the receptor-toxin complex. Pure IgG prepared from the serum of a myasthenic patient was as effective as the original serum in displacing ability. The possible effect of such antibodies on the correlation of antibody titre and disease state is discussed.

• Authors: T Barkas, J A Simpson
• Journal: Journal of clinical & laboratory immunology (J Clin Lab Immunol) Vol. 9 Issue 2 Pg. 113-7 (Nov 1982) ISSN: 0141-2760 [Print] Scotland
• PMID: 7154056 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Bungarotoxins
• Immunoglobulin G
• Receptors, Cholinergic
• Receptors, Nicotinic

Topics

• Antibody Specificity
• Autoantibodies (immunology)
• Binding, Competitive
• Bungarotoxins (metabolism)
• Humans
• Immunoglobulin G (immunology)
• Myasthenia Gravis (immunology)
• Receptors, Cholinergic (immunology)
• Receptors, Nicotinic (immunology, metabolism)