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Effect of heart rate and stroke volume on gas mixing in dog lung.

Abstract
In nine anesthetized and ventilated dogs heart block was induced at thoracotomy, a pacemaker was inserted, and an electromagnetic flow transducer was placed round the main pulmonary artery. The chest was then closed. Stroke volume (SV) was varied by changing central blood volume. Ventilatory dead space (VDS) and alveolar nitrogen mixing efficiency (ANME) were measured at three levels of heart rate (HR) and three levels of SV independently varied during life and also after cessation of heartbeat. Neither VDS nor ANME showed a significant change with HR or SV during life, but mean VDS increased by 43 ml (22%) and mean ANME decreased by 4.4% postmortem. We conclude that cardiac action increases gas mixing at the interface between inspired and resident gas but has only a small effect on gas mixing distal to the interface during respiration without breath holding.
AuthorsK Horsfield, I Gabe, C Mills, M Buckman, G Cumming
JournalJournal of applied physiology: respiratory, environmental and exercise physiology (J Appl Physiol Respir Environ Exerc Physiol) Vol. 53 Issue 6 Pg. 1603-7 (Dec 1982) ISSN: 0161-7567 [Print] United States
PMID7153156 (Publication Type: Journal Article)
Chemical References
  • Nitrogen
Topics
  • Animals
  • Cardiac Output
  • Cardiac Pacing, Artificial
  • Dogs
  • Heart Rate
  • Lung Volume Measurements
  • Nitrogen (physiology)
  • Pulmonary Alveoli (physiology)
  • Respiration
  • Respiratory Dead Space
  • Stroke Volume

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