Existence of an optimal dose of dihydroteleocidin B for skin tumor promotion.

Abstract

The tumor-promoting effects of various doses of dihydroteleocidin B, a catalytically hydrogenated derivative of teleocidin B isolated from Streptomyces mediocidicus, were examined in a two-stage carcinogenicity test on mouse skin. Doses of 1.25, 2.5 and 5.0 micrograms of dihydroteleocidin B dissolved in 0.1 ml acetone were applied twice a week to 7,12-dimethylbenz[a]anthracene-initiated mouse skin for 30 weeks. The maximal cumulative tumor incidence, tumor yield, latent period for 50% cumulative tumor incidence (t50) and amount of promoter needed for 50% cumulative tumor incidence (D50) were used to assess tumor-promoting activity. A dose of 2.5 micrograms of dihydroteleocidin B had the maximal tumor-promoting activity. The optimal dose of dihydroteleocidin B for tumor-promoting activity coincided with the optimal dose for ornithine decarboxylase induction.

• Authors: M Suganuma, H Fujiki, T Sugimura
• Journal: Gan (Gan) Vol. 73 Issue 4 Pg. 531-3 (Aug 1982) ISSN: 0016-450X [Print] Japan
• PMID: 7152193 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Lyngbya Toxins
• dihydroteleocidin B

Topics

• Alkaloids (administration & dosage)
• Animals
• Dose-Response Relationship, Drug
• Female
• Lyngbya Toxins
• Mice
• Neoplasms, Experimental (chemically induced)
• Skin Neoplasms (chemically induced)