[Studies on the pharmacokinetics of the compound preparation sulfamerazine/trimethoprim (Berlocombin-200) in pregnancy].

Abstract

Pharmacokinetics of the sulphamerazine/trimethoprim-combination Berlocombin-200 was calculated by an one-compartment-model following therapeutic administration in pregnant women and compared with a control group. Distribution parameters are significantly changed, but elimination half-lifes of both the sulphonamide and trimethoprim are not influenced by repeated administration during pregnancy. There are no consequences concerning the dosage of Berlocombin in bacterial infections during pregnancy.

• Authors: G Peiker, A Traeger, U Pischke, S Schröder, B Müller, H Nöschel
• Journal: Die Pharmazie (Pharmazie) Vol. 37 Issue 8 Pg. 578-83 (Aug 1982) ISSN: 0031-7144 [Print] Germany
• Vernacular Title: Untersuchungen zur Pharmakokinetik mit dem Kombinationspräparat Sulfamerazin/Trimethoprim (Berlocombin-200) in der Schwangerschaft.
• PMID: 7146066 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• trimerazine
• Trimethoprim
• Sulfamerazine

Topics

• Drug Combinations (metabolism)
• Female
• Half-Life
• Humans
• Kinetics
• Pregnancy
• Sulfamerazine (metabolism)
• Trimethoprim (metabolism)