Effect of coronary blood flow on uptake and washout of Tc-99m DMPE and Tl-201.

Abstract

After intravenous administration of Tc-99m DMPE the flow-dependent kinetics were studied in dogs during induced ischemia and during induced maximal reactive hyperemia. A control group was also studied. Mean time-activity curves obtained from the myocardial wall were compared within the same intervention group and also with other groups. During reactive hyperemia, there was a rapid and absolute increase in uptake followed by a rapid washout, whereas during ischemia there was a slow and decreased uptake followed by a slow washout. The magnitude of Tc-99m DMPE uptake during reactive hyperemia was slightly less than that of Tl-201, but the decreased uptake with ischemia was about equal for the two agents. Following maximal uptake in the myocardium the effective half-life of Tc-99m DMPE was one-third to one-fourth that of Tl-201. The similar kinetics of Tc-99m DMPE compared to Tl-201 suggests its usefulness in the evaluation of ischemic heart disease.

• Authors: H Nishiyama, R J Adolph, E Deutsch, V J Sodd, K Libson, M C Gerson, E L Saenger, S J Lukes, M Gabel, J L Vanderheyden, D L Fortman
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 23 Issue 12 Pg. 1102-10 (Dec 1982) ISSN: 0161-5505 [Print] United States
• PMID: 7143092 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Organotechnetium Compounds
• Phosphines
• Radioisotopes
• Technetium
• technetium Tc 99m bis(1,2-dimethylphosphino)ethane
• Thallium

Topics

• Animals
• Coronary Circulation
• Coronary Disease (diagnostic imaging)
• Dogs
• Hyperemia (diagnostic imaging)
• Kinetics
• Myocardium (metabolism)
• Organotechnetium Compounds
• Phosphines (metabolism)
• Radioisotopes
• Radionuclide Imaging
• Technetium (metabolism)
• Thallium (metabolism)