[Hypolipidemic properties of triterpenoids].

Abstract

Experiments on rabbits and white rats with experimental hyperlipidemia and atherosclerosis have shown that pentocyclic triterpenoids belonging to the alpha- and beta-amirin groups, of which saparal, glyciram and glycirenate are officinal drugs, are capable of reducing the level of cholesterol, beta-lipoproteins and triglycerides in the blood and that of cholesterol in aorta tissues. The effect of the compounds under study has been found to exceed the hypolipidemic action of the officinal antiatherosclerotic drugs, polysponine and cetamiphen, and to be noted for low toxicity. To screen hypolipidemic properties in the substances, an effective modification of experimental hyperlipidemia in rats has been offered.

• Authors: Iu K Vasilenko, L I Lisevitskaia, L M Frolova, E P Parfent'eva, I V Skul'te
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1982 Sep-Oct Vol. 45 Issue 5 Pg. 66-70 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Gipolipidemicheskie svoĭstva triterpenoidov.
• PMID: 7140959 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Cholesterol, Dietary
• Hypolipidemic Agents
• Lipids
• Triterpenes

Topics

• Animals
• Arteriosclerosis (blood, drug therapy)
• Cholesterol, Dietary (administration & dosage)
• Drug Evaluation, Preclinical
• Guinea Pigs
• Hyperlipidemias (blood, drug therapy)
• Hypolipidemic Agents (therapeutic use)
• Lipids (blood)
• Rabbits
• Rats
• Triterpenes (therapeutic use)