The mineralocorticoid hormone pathways in hypertension with hyperaldosteronism.

Abstract

Simultaneous measurement of the 0800-hr plasma concentrations of deoxycorticosterone (DOC), corticosterone (B), 18-hydroxycorticosterone (18-OHB), aldosterone, 18-hydroxydeoxycorticosterone (18-OHDOC) and cortisol (F) in four types of primary aldosteronism provides evidence for primary adrenal disease. Elevated DOC with normal F concentrations in the presence of elevated 18-OHB and aldosterone, and suppressed renin concentration suggests a primary adrenal abnormality of the zona glomerulosa (ZG). Steroid production by the zona fasciculata (ZF), F, 18-OHDOC, and most often B, is normal. These patterns exist only for primary adrenal hyperplasia, aldosterone-producing adenoma (APA), and aldosterone-producing adrenocortical carcinoma (AP-Ca). Elevated DOC levels are rarely found in patients with idiopathic hyperaldosteronism (IHA or adrenal hyperplasia) and suggest that IHA is not a primary adrenal disorder and should be excluded from the syndrome of primary aldosteronism as they have been heretofore.

• Authors: E G Biglieri, C E Kater, N Brust, B Chang, J Hirai
• Journal: Clinical and experimental hypertension. Part A, Theory and practice (Clin Exp Hypertens A) Vol. 4 Issue 9-10 Pg. 1677-83 ( 1982) ISSN: 0730-0077 [Print] United States
• PMID: 7139973 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 18-Hydroxydesoxycorticosterone
• Mineralocorticoids
• Desoxycorticosterone
• Aldosterone
• Corticosterone
• Hydrocortisone

Topics

• 18-Hydroxydesoxycorticosterone (blood)
• Adenoma (complications, diagnosis)
• Aldosterone (blood)
• Corticosterone (blood)
• Desoxycorticosterone (blood)
• Hydrocortisone (blood)
• Hyperaldosteronism (blood, complications)
• Hypertension (blood, complications)
• Mineralocorticoids (blood)