[Cellular immunity factors in the pathogenesis of recurrences of chronic herpetic infection].

Abstract

Comparative studies of various factors of cellular immunity in human chronic herpetic stomatitis (CHS) in periods of relapses and remission of the infection revealed no significant changes in specific cellular immune response, blasttransformation of lymphocytes to herpes simplex virus antigen. At the same time, the indices of nonspecific cellular responsiveness: the rosette-forming activity of T-lymphocytes and the level of leukocyte interferon were markedly reduced in the period of recurrence of the infection and increased as remission developed. The role of immune factors in the pathogenesis of herpes relapses is discussed.

• Authors: R M Bikbulatov, S A Demidova, T Ia Liarskaia, A F Bocharov, G I Savitskiĭ
• Journal: Voprosy virusologii (Vopr Virusol) 1982 Jul-Aug Vol. 27 Issue 4 Pg. 488-90 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Faktory kletochnogo immuniteta v patogeneze retsidivov khronicheskoĭ gerpeticheskoĭ infektsii.
• PMID: 7135930 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Interferon Type I

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Chronic Disease
• Humans
• Immunity, Cellular
• Immunity, Innate
• Interferon Type I (immunology)
• Lymphocyte Activation
• Middle Aged
• Recurrence
• Rosette Formation
• Stomatitis, Herpetic (etiology, immunology)