Abstract |
Classic mouse skin-painting assays of such highly- complex mixtures as petroleums and synthetic fuels may lead to severe local cytotoxic effects that can alter tumorigenesis. This effect can be particularly disruptive in dose-response studies where a wide range of doses is employed. The experiments described here illustrate that frequency of exposure may be more important than the concentration of individual doses. C3Hf/Bd mice were exposed to 2 shale oils in experiments in which a constant weekly dose was either applied once or divided into 2 or 4 equal parts and applied either twice or 4 times each week. In experiments with either oil, a single weekly application was more effective in total tumor production and less cytotoxic than more frequent application of less-concentrated doses.
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Authors | J S Wilson, L M Holland |
Journal | Toxicology
(Toxicology)
Vol. 24
Issue 1
Pg. 45-53
( 1982)
ISSN: 0300-483X [Print] Ireland |
PMID | 7135403
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Animals
- Carcinogens
(toxicity)
- Mice
- Mice, Inbred C3H
- Neoplasms, Experimental
(chemically induced)
- Petroleum
(toxicity)
- Skin
(drug effects)
- Skin Neoplasms
(chemically induced)
- Time Factors
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