[Acute nadoxolol poisoning. A multicentric study of 35 cases].

Abstract

Between 1976 and 1980, 35 cases of nadoxolol poisoning were collected from french antipoison centers. Acute intoxication was voluntary (50%) or accidental (50%). The ingested dose ranged between 0,25 and 22,5 g. Clinical symptoms appeared three hours after ingestion and consisted of cardio-vascular disorders which were present in 10 patients: bradycardia (7 cases), cardiogenic shock (6 cases), intraventricular block (5 cases), increase of P.R. interval (4 cases) and Q.T. interval (3 cases). The toxic dose in otherwise healthy adults was 5 g. The treatment consisted of gastric lavage and correction of cardiovascular disorders with sodium lactate (4 cases) or dopamine (1 case). All the patients recovered.

• Authors: A Jaeger, J Kopferschmitt, P Sauder, A Benmatti, J M Mantz
• Journal: Toxicological European research. Recherche europeenne en toxicologie (Toxicol Eur Res) Vol. 4 Issue 3 Pg. 163-6 (May 1982) ISSN: 0249-6402 [Print] France
• Vernacular Title: Les intoxications aiguës par le nadoxolol. Etude multicentrique de 35 observations.
• PMID: 7135390 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lactates
• Oximes
• Lactic Acid
• nadoxolol
• Dopamine

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Cardiovascular Diseases (chemically induced)
• Child, Preschool
• Dopamine (therapeutic use)
• Electrocardiography
• Humans
• Infant
• Lactates (therapeutic use)
• Lactic Acid
• Middle Aged
• Nervous System Diseases (chemically induced)
• Oximes (poisoning)
• Therapeutic Irrigation