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[Comparative double blind study of pirprofen, indomethacin, and placebo in the treatment of osteoarthritis of the spine].

Abstract
137 out-patients suffering from osteoarthritis of the spine were treated for two-weeks by pirprofen (600 mg/day), indomethacin (75 mg/day), or placebo. At the end of the trial, spontaneous pain disappeared in 47% of patients in the pirprofen group, 38% in the indomethacin group, and 17% in the placebo group. The efficacy of pirprofen and indomethacin, compared to the placebo, is demonstrated with respect to both spontaneous pain (p less than 0,01) and functional disorders (p less than 0,05). Side effects, especially digestive, were noted in 29% of patients treated by pirprofen, 33% of those treated by indomethacin and 17% of those on placebo. Tolerance was satisfactory in 86%, 80% and 90% of patients. Pirprofen is thus judged an effective drug for the treatment of osteoarthritis of the spine.
AuthorsB Dolanc, E Morscher
JournalLa Nouvelle presse medicale (Nouv Presse Med) Vol. 11 Issue 33 Pg. 2500-2 (Aug 28 1982) ISSN: 0301-1518 [Print] France
Vernacular TitleEtude comparative en double insu du pirprofène, de l'indométacine et d'un placebo dans le traitement de l'arthrose vertébrale.
PMID7133973 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Phenylpropionates
  • Placebos
  • pirprofen
  • Indomethacin
Topics
  • Anti-Inflammatory Agents (adverse effects, therapeutic use)
  • Double-Blind Method
  • Female
  • Humans
  • Indomethacin (adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Osteoarthritis (drug therapy)
  • Phenylpropionates (adverse effects, therapeutic use)
  • Placebos
  • Spinal Diseases (drug therapy)

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