Failure to demonstrate a role for line Ib tumor-associated surface antigen in the etiology of age-dependent polioencephalomyelitis.

Abstract

In the preceding paper [Morris et al. (1982), Molec. Immun. 19, 973-982] we demonstrate an associative interaction between the line Ib tumor-associated surface antigen (Ib-TASA) and the Dk/Kk regions of the major histocompatibility complex, i.e. 'altered-self' antigen. We originally hypothesized that age-dependent polioencephalomyelitis (ADPE) occurred as the result of immune recognition of a 'self'-determinant on the 'altered-self' antigen. In this report we used the non-ionic detergent, NP-40, to solubilize Ib cell surface antigens. Although immunization of immunocompetent C58 mice with the soluble NP-40 Ib cell extract afforded protection to lethal tumor challenge, the extract failed to induce ADPE in immunosuppressed mice. Data presented here demonstrate that Ib-TASA is not involved in the etiology of ADPE. The evidence suggests that lactic dehydrogenase virus, which is a silent virus passaged with line Ib leukemia, is the causative agent of the paralytic disease.

• Authors: D M Bentley, V A Guckian, J D Stinnett, R E Morris
• Journal: Molecular immunology (Mol Immunol) Vol. 19 Issue 8 Pg. 983-9 (Aug 1982) ISSN: 0161-5890 [Print] England
• PMID: 7132971 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antigens, Neoplasm
• Antigens, Surface
• L-Lactate Dehydrogenase

Topics

• Age Factors
• Animals
• Antigens, Neoplasm (immunology)
• Antigens, Surface (immunology)
• Cell Line
• Encephalomyelitis (etiology, immunology, microbiology)
• L-Lactate Dehydrogenase (metabolism)
• Lactate dehydrogenase-elevating virus (enzymology)
• Lymphocytes (immunology)
• Mice
• Mice, Inbred BALB C
• Poliomyelitis (etiology, immunology, microbiology)