Acute thioproline poisoning.

Abstract

Thiazolidine-4-carboxylic acid (A.T.C.) has been marketed in France since 1964 for the treatment of hepatic and biliary disorders. [Hepalidine (Riker Lab.): Packs of 20 tablets, each containing 100 mg. Thiobiline (Riker Lab.): Packs of 20 vials, each containing 100 mg.] As early as 1970, both the Paris and Marseilles Poison Control Centres had emphasized the toxicity of this drug which induces convulsions in children subject of overdosage [1]. Brugarolas and Gosalvez have recently suggested the use of A.T.C. in the treatment of epidermoid carcinoma. They believe that the drug causes reverse transformation of tumor cells to normal ones [2]. If its efficiency is confirmed, A.T.C. should soon be very widely used and therefore its therapeutic risk needs to be clarified.

• Authors: R Garnier, M L Efthymiou, E Fournier
• Journal: Journal of toxicology. Clinical toxicology (J Toxicol Clin Toxicol) Vol. 19 Issue 3 Pg. 289-95 (May 1982) ISSN: 0731-3810 [Print] United States
• PMID: 7131615 (Publication Type: Journal Article)

Chemical References

• Thiazoles
• Thiazolidines
• thiazolidine-4-carboxylic acid

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Female
• France
• Humans
• Infant
• Male
• Seizures (chemically induced)
• Thiazoles (poisoning)
• Thiazolidines