Oral pulse prednisone therapy in the treatment of HBsAg negative chronic active hepatitis.

• Abstract: A young woman with hepatitis B surface antigen negative chronic active hepatitis and hypergammaglobulinemia was treated successfully with oral pulse steroid therapy consisting of prednisone, 90 mg/day, given in repeated 3--5-day courses at 3--4-wk intervals. This approach, which is hypothetically founded on the ability of steroids to cause prolonged inhibition of immunoglobulin G synthesis and proposed mechanisms of hepatocellular damage in chronic active hepatitis, permitted complete clinical, chemical, and histologic remission without morbidity. Oral pulse prednisone therapy deserves further study as a possible adjunct or alternative to existing methods of managing hepatitis B surface antigen negative chronic active hepatitis associated with hypergammaglobulinemia.
• Authors: W F Chase, R E Winn, G R Mayes
• Journal: Gastroenterology (Gastroenterology) Vol. 83 Issue 6 Pg. 1292-6 (Dec 1982) ISSN: 0016-5085 [Print] UNITED STATES
• PMID: 7129032 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hepatitis B Surface Antigens
• Prednisone

Topics

• Administration, Oral
• Adolescent
• Drug Administration Schedule
• Female
• Hepatitis B Surface Antigens (analysis)
• Hepatitis, Chronic (drug therapy, immunology, pathology)
• Humans
• Liver (pathology)
• Prednisone (administration & dosage)