Atropine and mepenzolate mydriasis in rabbits: a comparative pupillographic analysis of two antimuscarinic agents.

Abstract

The mydriatic effects of mepenzolate, a quarternary antimuscarinic agent, has been investigated and compared with those of atropine by pupillographic analysis in rabbits. The time-response curve for the onset of action for the agents (half-time, ca.5 min) was the same for the two agents despite the difference in structures. Although the half time for the offset of action (ca.18 and 34 hrs. for atropine and mepenzolate respectively) was different, the mydriatic effects of both agents were completely eliminated in 74 hrs.

• Authors: R F Ochillo, D A Pugh
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 36 Issue 3 Pg. 503-6 (Jun 1982) ISSN: 0034-5164 [Print] United States
• PMID: 7122991 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzilates
• Mydriatics
• Parasympatholytics
• Piperidines
• Receptors, Cholinergic
• Receptors, Muscarinic
• mepenzolic acid
• Atropine

Topics

• Animals
• Atropine (pharmacology)
• Benzilates (pharmacology)
• Mydriatics (pharmacology)
• Parasympatholytics (pharmacology)
• Piperidines (pharmacology)
• Rabbits
• Receptors, Cholinergic (drug effects)
• Receptors, Muscarinic (drug effects)