HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Perfusion of the fourth cerebral ventricle with the synthetic opioid peptide, FK 33-824, induces dose-related bradycardia and naloxone-reversible respiratory depression in the awake dog.

Abstract
The importance of natural opioids in the central control of blood pressure, heart rate and respiratory function was evaluated with a synthetic analogue of Met-enkephalin, FK 33-824, which is more resistant to enzymatic degradation than the natural opioids. Increasing concentrations (20, 100, 200 and 400 micrograms/ml), perfused through the 4th cerebral ventricle of the conscious dog, induced a concentration-related depression of respiratory function - as reflected in arterial pCO2 and pO2 and heart rate. Naloxone (40 micrograms/ml) was able to reverse respiratory depression whereas bradycardia was naloxone-resistant even after massive (100 micrograms/kg) intravenous doses. Mean arterial blood pressure was not affected in the tested concentration range. Because respiration was reversed by naloxone, it is concluded that respiratory control is regulated by the mu-type opioid receptor. Heart rate, however, may be governed by the delta-type opioid receptor which is less susceptible to naloxone.
AuthorsE Freye, E Hartung, G K Schenk
JournalPharmacology (Pharmacology) Vol. 25 Issue 1 Pg. 6-11 ( 1982) ISSN: 0031-7012 [Print] Switzerland
PMID7122692 (Publication Type: Journal Article)
Chemical References
  • Naloxone
  • Enkephalin, Methionine
  • D-Ala(2),MePhe(4),Met(0)-ol-enkephalin
Topics
  • Animals
  • D-Ala(2),MePhe(4),Met(0)-ol-enkephalin
  • Depression, Chemical
  • Dogs
  • Dose-Response Relationship, Drug
  • Enkephalin, Methionine (administration & dosage, analogs & derivatives, pharmacology)
  • Heart Rate (drug effects)
  • Injections, Intraventricular
  • Naloxone (pharmacology)
  • Respiration (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: