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Gamma fetal antigen in spontaneous and carcinogen-induced rodent tumors. Survey of sarcomas and hepatic carcinomas.

Abstract
Fourteen distinct rodent sarcomas and hepatic carcinomas were examined serologically for the presence of the tumor-associated gamma fetal antigen (gamma-FA). Using heterologous antiserum specific for gamma-FA, this antigen could be identified in saline extracts of each of the tumors surveyed; animals bearing gamma-FA-positive cancers had immunoprecipitable levels of gamma-FA in their sera. Although gamma-FA was associated with hepatic neoplasms of diverse phenotypes, low- or non-albumin-producing tumors had more gamma-FA per milligram of saline-extractable protein than did the more differentiated hepatocellular carcinomas. Gamma-FA became detectable in the sera of BALB/c mice bearing transplanted Meth A sarcomas and hepatocarcinogen-treated Wistar rats early during the time course of tumor growth. These data strongly suggest that serum gamma-FA levels may serve as a useful monitor of tumor presence and progression.
AuthorsP J Higgins
JournalOncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine (Oncodev Biol Med) Vol. 3 Issue 2-3 Pg. 91-6 ( 1982) ISSN: 0167-1618 [Print] Netherlands
PMID7122258 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Neoplasm
  • Fetal Proteins
  • gamma-fetal antigen
Topics
  • Animals
  • Antigens, Neoplasm (analysis)
  • Fetal Proteins (analysis)
  • Liver Neoplasms (immunology)
  • Mice
  • Neoplasm Transplantation
  • Rats
  • Sarcoma, Experimental (immunology)

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