Abstract |
Fourteen distinct rodent sarcomas and hepatic carcinomas were examined serologically for the presence of the tumor-associated gamma fetal antigen (gamma-FA). Using heterologous antiserum specific for gamma-FA, this antigen could be identified in saline extracts of each of the tumors surveyed; animals bearing gamma-FA-positive cancers had immunoprecipitable levels of gamma-FA in their sera. Although gamma-FA was associated with hepatic neoplasms of diverse phenotypes, low- or non- albumin-producing tumors had more gamma-FA per milligram of saline-extractable protein than did the more differentiated hepatocellular carcinomas. Gamma-FA became detectable in the sera of BALB/c mice bearing transplanted Meth A sarcomas and hepatocarcinogen-treated Wistar rats early during the time course of tumor growth. These data strongly suggest that serum gamma-FA levels may serve as a useful monitor of tumor presence and progression.
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Authors | P J Higgins |
Journal | Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine
(Oncodev Biol Med)
Vol. 3
Issue 2-3
Pg. 91-6
( 1982)
ISSN: 0167-1618 [Print] Netherlands |
PMID | 7122258
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antigens, Neoplasm
- Fetal Proteins
- gamma-fetal antigen
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Topics |
- Animals
- Antigens, Neoplasm
(analysis)
- Fetal Proteins
(analysis)
- Liver Neoplasms
(immunology)
- Mice
- Neoplasm Transplantation
- Rats
- Sarcoma, Experimental
(immunology)
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