Topical 5-fluorouracil treatment of transformation zone intraepithelial neoplasia of cervix and vagina.

Abstract

The authors present preliminary findings in 11 unselected patients with upper vaginal and/or cervical transformation zone intraepithelial neoplasia treated with a 5% topical 5-fluorouracil (5-FU) cream. Only 6 of 11 patients were found to be cured of disease when subsequently evaluated histologically by conization biopsy and/or hysterectomy. Although further clinical trials using differing concentrations and/or more prolonged exposure to the drug may be warranted, the authors cannot recommend topical 5-FU as a replacement for standard outpatient therapy for upper vaginal and/or cervical intraepithelial neoplasia.

• Authors: G L Pride, T W Chuprevich
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 60 Issue 4 Pg. 467-72 (Oct 1982) ISSN: 0029-7844 [Print] United States
• PMID: 7121934 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Fluorouracil

Topics

• Administration, Topical
• Carcinoma in Situ (drug therapy)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Uterine Cervical Dysplasia (drug therapy)
• Uterine Cervical Neoplasms (drug therapy, pathology)
• Vaginal Neoplasms (drug therapy, pathology)