Abstract |
The anti-inflammatory activities of oleanane triterpenoid glycosides, papyrioside L-IIa, L-IIb, L-IIc and L-IId, extracted from Tetrapanax papyriferum (Araliaceae), and their aglycones, papyriogenin A and C and propapyriogenin A1 and A2, were investigated by using the carrageenin-induced edema and the cotton pellet granuloma tests in mice. Of these compounds, papyriogenin A and C (30 mg/kg p.o.) manifested in these tests almost the same potency as prednisolone (25 mg/kg p.o.). The structure-activity relationships of these and related triterpenes have been investigated. This takes into account particularly variation in the oxygen function and the molecular conformation. We have found that the anti-inflammatory activity of these triterpenes was favoured when the molecules tended to take a planar conformation; this was induced by the heteroanulardiene group between C and D ring.
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Authors | E Sugishita, S Amagaya, Y Ogihara |
Journal | Journal of pharmacobio-dynamics
(J Pharmacobiodyn)
Vol. 5
Issue 6
Pg. 379-87
(Jun 1982)
ISSN: 0386-846X [Print] Japan |
PMID | 7120036
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Glycosides
- Plant Extracts
- Triterpenes
- Prednisolone
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Topics |
- Animals
- Anti-Inflammatory Agents
- Body Weight
(drug effects)
- Drug Interactions
- Glycosides
(pharmacology)
- Granuloma
(drug therapy)
- Male
- Mice
- Plant Extracts
(pharmacology)
- Prednisolone
(pharmacology)
- Structure-Activity Relationship
- Time Factors
- Triterpenes
(pharmacology)
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