| Abstract | Bromocriptine (Parlodel) was given for 2 years to 17 parkinsonian patients showing inadequate response to treatment over a mean of 7 years with levodopa combined with a decarboxylase inhibitor. 11 of the patients had developed dyskinesia and 13 the on-off phenomenon during levodopa therapy. When the dose of bromocriptine reached 30 mg daily, after 4 weeks' treatment, a highly significant improvement (p less than 0.001) was observed in the following six variables: bradykinesia, rigidity, tremor, feeding, dressing and speech. These improvements have now been maintained for 2 years. The on-off phenomenon disappeared in 9 out of 13 patients. Side effects were mild and transient. Involuntary movements existing prior to bromocriptine administration were improved by reducing the dose of levodopa. The mean daily dose--after progressive and individual adjustment--was 46 mg bromocriptine combined with 435 mg levodopa plus decarboxylase inhibitor. |
| Authors | G Gauthier, A Martins da Silva |
| Journal | European neurology
(Eur Neurol)
Vol. 21
Issue 4
Pg. 217-26
( 1982)
ISSN: 0014-3022 SWITZERLAND |
| PMID | 7117308
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
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| Topics |
- Aged
- Bromocriptine
(adverse effects, therapeutic use)
- Drug Therapy, Combination
- Humans
- Levodopa
(adverse effects, therapeutic use)
- Middle Aged
- Motor Skills
- Parkinson Disease
(drug therapy)
|
