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In vivo anti-cancer activity of RC-18: a plant isolate from Rubia cordifolia, Linn. against a spectrum of experimental tumour models.

Abstract
Anti-tumour activity of RC-18, a pure isolate from Rubia cordifolia was repeatedly tested in different sets of experiments on a spectrum of experimental murine tumours, viz. P388, L1210, L5178Y, B16 melanoma, Lewis lung carcinoma and sarcoma-180. RC-18 exhibited significant increase in life span of ascites leukaemia P388, L1210, L5178Y and a solid tumour B16 melanoma. However, it failed to show any inhibitory effect on solid tumours, Lewis lung carcinoma and sarcoma 180. Promising results against a spectrum of experimental tumours suggest that RC-18 may lead to the development of a potential anti-cancer agent.
AuthorsM K Adwankar, M P Chitnis
JournalChemotherapy (Chemotherapy) Vol. 28 Issue 4 Pg. 291-3 ( 1982) ISSN: 0009-3157 [Print] Switzerland
PMID7116981 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • RC-18
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (therapeutic use)
  • Drug Evaluation, Preclinical
  • Leukemia, Experimental (drug therapy)
  • Lung Neoplasms (drug therapy)
  • Melanoma (drug therapy)
  • Mice
  • Neoplasms, Experimental (drug therapy)
  • Plant Extracts
  • Sarcoma 180 (drug therapy)

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