Abstract |
Anti-tumour activity of RC-18, a pure isolate from Rubia cordifolia was repeatedly tested in different sets of experiments on a spectrum of experimental murine tumours, viz. P388, L1210, L5178Y, B16 melanoma, Lewis lung carcinoma and sarcoma-180. RC-18 exhibited significant increase in life span of ascites leukaemia P388, L1210, L5178Y and a solid tumour B16 melanoma. However, it failed to show any inhibitory effect on solid tumours, Lewis lung carcinoma and sarcoma 180. Promising results against a spectrum of experimental tumours suggest that RC-18 may lead to the development of a potential anti- cancer agent.
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Authors | M K Adwankar, M P Chitnis |
Journal | Chemotherapy
(Chemotherapy)
Vol. 28
Issue 4
Pg. 291-3
( 1982)
ISSN: 0009-3157 [Print] Switzerland |
PMID | 7116981
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Plant Extracts
- RC-18
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(therapeutic use)
- Drug Evaluation, Preclinical
- Leukemia, Experimental
(drug therapy)
- Lung Neoplasms
(drug therapy)
- Melanoma
(drug therapy)
- Mice
- Neoplasms, Experimental
(drug therapy)
- Plant Extracts
- Sarcoma 180
(drug therapy)
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