Acute oral toxicity of 4-dimethylaminophenol to the gastrointestinal tract, liver and kidney of the rat.

Abstract

Single oral doses up to 25 mg/kg body weight of methaemoglobin-inducing cyanide antidote, 4-dimethylaminophenol (DMAP) did not result in any gross or histological abnormality in the gastrointestinal tract, liver and kidneys of rats killed up to 24 h after the dose. In animals kept for 7 days after the dose to abnormality was observed in the organs examined or in blood samples taken during the course of the experiment.

• Authors: T C Marrs, J E Bright, D W Swanston
• Journal: Archives of toxicology (Arch Toxicol) Vol. 50 Issue 1 Pg. 89-92 (May 1982) ISSN: 0340-5761 [Print] Germany
• PMID: 7115083 (Publication Type: Journal Article)

Chemical References

• Aminophenols
• 4-dimethylaminophenol

Topics

• Aminophenols (toxicity)
• Animals
• Chemical and Drug Induced Liver Injury (etiology)
• Female
• Gastrointestinal Diseases (chemically induced)
• Heinz Bodies (drug effects)
• Kidney Diseases (chemically induced)
• Rats
• Rats, Inbred Strains
• Time Factors