Effects of naloxone in hemorrhagic shock.

Abstract	The endorphins appear to play an integral role in the physiopathology of hemorrhagic shock. Blockade of these endodgenous opiates by naloxone can significantly alter the course of this syndrome. While the administration of naloxone to normal rats had no effect upon the circulation or cellular function, it improved the hemodynamic status of rats subjected to hemorrhagic shock, resulting in improved tissue perfusion. In addition, the administration of this drug prevented the cellular dysfunction normally seen in hemorrhagic shock. This effect was independent of its salutary effects upon the circulation.
Authors	S A Albert, G T Shires 3rd, H Illner, G T Shires
Journal	Surgery, gynecology & obstetrics (Surg Gynecol Obstet) Vol. 155 Issue 3 Pg. 326-32 (Sep 1982) ISSN: 0039-6087 [Print] United States
PMID	7112361 (Publication Type: Comparative Study, Journal Article)
Chemical References	Bicarbonates Naloxone Potassium
Topics	Animals Bicarbonates (blood) Blood Circulation (drug effects) Blood Pressure (drug effects) Cell Membrane (drug effects) Hemodynamics (drug effects) Homeostasis (drug effects) Male Muscles (drug effects) Naloxone (pharmacology) Potassium (blood) Rats Rats, Inbred Strains Shock, Hemorrhagic (physiopathology) Tissue Distribution

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