Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.

Abstract

Cytogenic studies were performed on the direct chromosome preparations of the renal cell carcinoma cells and the cultured peripheral blood lymphocytes of a patient with familial renal cell carcinoma. The results revealed a specific, acquired translocations (3p;11p) present in the majority of metaphases of the tumor, indicating that the development of renal cell carcinoma is associated with a deletion in the proximal end of 3p. Renal cell carcinoma is thus the third example--the first two being retinoblastoma and Wilms' tumor--of a chromosomal deletion occurring germinally or somatically in association with a specific tumor. This finding adds further support to the existence of specific human cancer genes.

• Authors: S Pathak, L C Strong, R E Ferrell, A Trindade
• Journal: Science (New York, N.Y.) (Science) Vol. 217 Issue 4563 Pg. 939-41 (Sep 03 1982) ISSN: 0036-8075 [Print] United States
• PMID: 7112106 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Adenocarcinoma (genetics)
• Adult
• Chromosome Banding
• Chromosomes, Human, 1-3 (ultrastructure)
• Chromosomes, Human, 6-12 and X (ultrastructure)
• Female
• Humans
• Karyotyping
• Kidney Neoplasms (genetics)
• Lymphocytes (ultrastructure)
• Male
• Pedigree
• Translocation, Genetic