Saline- and glycerol-induced acute renal failure: 'protection' occurs after insult.

Abstract

To determine whether chronic saline ingestion is required for protection against acute renal failure, we examined the effect of the time at which saline was offered. Water-drinking rats developed severe azotemia (BUN 115 +/- 6 mg/dl; 41 +/- 2 mmol/l) 24 h after 50% glycerol i.m. Chronic saline ingestion for 30 days conferred protection only if continued after the insult (BUN 49 +/- 4 mg/dl; 18 +/- 1 mmol/l; p less than 0.01) but not if saline was withdrawn (BUN 110 +/- 8 mg/dl; 38 +/- 3 mmol/l). Moreover, saline offered only after the insult conferred equivalent protection (BUN 57 +/- 6 mg/dl; 32 +/- 2 mmol/l). Fluid intake, arterial blood pressure and plasma volume were better sustained in saline-drinking rats.

• Authors: B M Wilkes, N K Hollenberg
• Journal: Nephron (Nephron) Vol. 30 Issue 4 Pg. 352-6 ( 1982) ISSN: 1660-8151 [Print] Switzerland
• PMID: 7110466 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Sodium Chloride
• Glycerol

Topics

• Acute Kidney Injury (chemically induced, prevention & control)
• Animals
• Blood Urea Nitrogen
• Drinking
• Glycerol
• Male
• Rats
• Rats, Inbred Strains
• Renin-Angiotensin System
• Sodium Chloride (pharmacology)