Antitumor activity in mice of orally administered polysaccharide from Kefir grain.

Abstract

The antitumor activity of a water-soluble polysaccharide (KGF-C), isolated from the Kefir grain, was studied in the mice subcutaneously inoculated with Ehrlich carcinoma (EC) or Sarcoma 180 (S-180). The growth of EC and S-180 solid tumor was inhibited by 40-59% and 21-81%, respectively, by oral administration of KGF-C as compared with the unadministered mice. The tumor growth was similarly inhibited by intraperitoneal administration. The mechanism of the antitumor activity of KGF-C was considered to be host-mediated because of the lack of direct in vitro effect on tumor cells.

• Authors: M Shiomi, K Sasaki, M Murofushi, K Aibara
• Journal: Japanese journal of medical science & biology (Jpn J Med Sci Biol) Vol. 35 Issue 2 Pg. 75-80 (Apr 1982) ISSN: 0021-5112 [Print] Japan
• PMID: 7109321 (Publication Type: Journal Article)

Chemical References

• Polysaccharides

Topics

• Animals
• Carcinoma, Ehrlich Tumor (drug therapy, physiopathology)
• Cell Division (drug effects)
• Cell Survival (drug effects)
• Edible Grain
• Mice
• Plants, Medicinal
• Polysaccharides (therapeutic use)
• Sarcoma 180 (drug therapy, physiopathology)